CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase. Until now, the regulation that restricts CMG ubiquityl...

Descripción completa

Detalles Bibliográficos
Autores principales: Deegan, Tom D, Mukherjee, Progya P, Fujisawa, Ryo, Polo Rivera, Cristian, Labib, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462611/
https://www.ncbi.nlm.nih.gov/pubmed/32804080
http://dx.doi.org/10.7554/eLife.60371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462611/
https://www.ncbi.nlm.nih.gov/pubmed/32804080
http://dx.doi.org/10.7554/eLife.60371

Ejemplares similares