AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications

Oncogene amplification, a major driver of cancer pathogenicity, is often mediated through focal amplification of genomic segments. Recent results implicate extrachromosomal DNA (ecDNA) as the primary driver of focal copy number amplification (fCNA) - enabling gene amplification, rapid tumor evolutio...

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Detalles Bibliográficos
Autores principales: Luebeck, Jens, Coruh, Ceyda, Dehkordi, Siavash R., Lange, Joshua T., Turner, Kristen M., Deshpande, Viraj, Pai, Dave A., Zhang, Chao, Rajkumar, Utkrisht, Law, Julie A., Mischel, Paul S., Bafna, Vineet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463033/
https://www.ncbi.nlm.nih.gov/pubmed/32873787
http://dx.doi.org/10.1038/s41467-020-18099-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463033/
https://www.ncbi.nlm.nih.gov/pubmed/32873787
http://dx.doi.org/10.1038/s41467-020-18099-z

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