Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients

Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric acute lymphoblastic leukemia. Recently, NUDT15 variants were identified as a major determinant of mercaptopurine intolerance. Two NUDT15 variants, c.36_37insGGAGTC and c.415C > T, are located on exons 1...

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Detalles Bibliográficos
Autores principales: Yu, Chih-Hsiang, Chang, Ya-Hsuan, Wang, Der-Shiun, Jou, Shiann-Tarng, Lin, Chien-Yu, Lin, Kai-Hsin, Lu, Meng-Yao, Raghav, Lovely, Chang, Hsiu-Hao, Wu, Kang-Hsi, Chou, Shu-Wei, Ni, Yu-Ling, Lin, Dong-Tsamn, Lin, Shu-Wha, Chen, Hsuan-Yu, Yang, Yung-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463237/
https://www.ncbi.nlm.nih.gov/pubmed/32873882
http://dx.doi.org/10.1038/s41598-020-71468-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463237/
https://www.ncbi.nlm.nih.gov/pubmed/32873882
http://dx.doi.org/10.1038/s41598-020-71468-y

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