Population‐level multiplexing: A promising strategy to manage the evolution of resistance against gene drives targeting a neutral locus

CRISPR‐based gene drives bias inheritance in their favour by inducing double‐stranded breaks (DSBs) at wild‐type homologous loci and using the drive transgene as a repair template—converting drive heterozygotes into homozygotes. Recent studies have shown that alternate end‐joining repair mechanisms...

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Detalles Bibliográficos
Autores principales: Edgington, Matthew P., Harvey‐Samuel, Tim, Alphey, Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463328/
https://www.ncbi.nlm.nih.gov/pubmed/32908596
http://dx.doi.org/10.1111/eva.12945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463328/
https://www.ncbi.nlm.nih.gov/pubmed/32908596
http://dx.doi.org/10.1111/eva.12945

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