Novel C‐terminal heat shock protein 90 inhibitors target breast cancer stem cells and block migration, self‐renewal, and epithelial–mesenchymal transition

In patients with triple‐negative breast cancer (TNBC), evidence suggests that tumor‐initiating cells (TIC) have stem cell‐like properties, leading to invasion and metastasis. HSP90 plays a critical role in the conformational maintenance of many client proteins in TIC development. Therefore, we hypot...

Descripción completa

Detalles Bibliográficos
Autores principales: Subramanian, Chitra, Grogan, Patrick T., Wang, Ton, Bazzill, Joseph, Zuo, Ang, White, Peter T., Kalidindi, Avinaash, Kuszynski, Dawn, Wang, Grace, Blagg, Brian S. J., Cohen, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463342/
https://www.ncbi.nlm.nih.gov/pubmed/32255264
http://dx.doi.org/10.1002/1878-0261.12686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463342/
https://www.ncbi.nlm.nih.gov/pubmed/32255264
http://dx.doi.org/10.1002/1878-0261.12686

Ejemplares similares