SUMOylation modulates the LIN28A‐let‐7 signaling pathway in response to cellular stresses in cancer cells

LIN28A is a conserved RNA‐binding protein that inhibits the biogenesis of let‐7 microRNAs, thus promoting cancer progression. However, mechanisms underlying the activation of the LIN28A‐let‐7 signaling pathway remain poorly understood. Here, we show that LIN28A is SUMOylated in vivo and in vitro at...

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Detalles Bibliográficos
Autores principales: Dou, Jinzhuo, Zhang, Hailong, Chen, Ran, Shu, Zimei, Yuan, Haihua, Zhao, Xian, Wang, Yanli, Huang, Jian, Zhou, Aiwu, Yu, Jianxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463354/
https://www.ncbi.nlm.nih.gov/pubmed/32333719
http://dx.doi.org/10.1002/1878-0261.12694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463354/
https://www.ncbi.nlm.nih.gov/pubmed/32333719
http://dx.doi.org/10.1002/1878-0261.12694

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