Autocrine Signaling of NRP1 Ligand Galectin-1 Elicits Resistance to BRAF-Targeted Therapy in Melanoma Cells

Melanoma cells addicted to mutated BRAF oncogene activity can be targeted by specific kinase inhibitors until they develop resistance to therapy. We observed that the expression of Galectin-1 (Gal-1), a soluble ligand of Neuropilin-1 (NRP1), is upregulated in melanoma tumor samples and melanoma cell...

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Detalles Bibliográficos
Autores principales: Rizzolio, Sabrina, Corso, Simona, Giordano, Silvia, Tamagnone, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463444/
https://www.ncbi.nlm.nih.gov/pubmed/32784465
http://dx.doi.org/10.3390/cancers12082218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463444/
https://www.ncbi.nlm.nih.gov/pubmed/32784465
http://dx.doi.org/10.3390/cancers12082218

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