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Structure and Antiparasitic Activity Relationship of Alkylphosphocholine Analogues against Leishmania donovani
Miltefosine (Milt) is the only oral treatment for visceral leishmaniasis (VL) but its use is associated with adverse effects, e.g., teratogenicity, vomiting, diarrhoea. Understanding how its chemical structure induces cytotoxicity, whilst not compromising its anti-parasitic efficacy, could identify...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463460/ https://www.ncbi.nlm.nih.gov/pubmed/32722326 http://dx.doi.org/10.3390/microorganisms8081117 |