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Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression
The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate decisions in both embryonic and adult life. Several aspects of stem cell maintenance are dependent from the functionality and fine tuning of the Notch pathway. In cancer, Notch is specifically involved in pre...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463613/ https://www.ncbi.nlm.nih.gov/pubmed/32796631 http://dx.doi.org/10.3390/cells9081879 |
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author | Meisel, Christian T. Porcheri, Cristina Mitsiadis, Thimios A. |
author_facet | Meisel, Christian T. Porcheri, Cristina Mitsiadis, Thimios A. |
author_sort | Meisel, Christian T. |
collection | PubMed |
description | The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate decisions in both embryonic and adult life. Several aspects of stem cell maintenance are dependent from the functionality and fine tuning of the Notch pathway. In cancer, Notch is specifically involved in preserving self-renewal and amplification of cancer stem cells, supporting the formation, spread and recurrence of the tumor. As the function of Notch signaling is context dependent, we here provide an overview of its activity in a variety of tumors, focusing mostly on its role in the maintenance of the undifferentiated subset of cancer cells. Finally, we analyze the potential of molecules of the Notch pathway as diagnostic and therapeutic tools against the various cancers. |
format | Online Article Text |
id | pubmed-7463613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74636132020-09-02 Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression Meisel, Christian T. Porcheri, Cristina Mitsiadis, Thimios A. Cells Review The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate decisions in both embryonic and adult life. Several aspects of stem cell maintenance are dependent from the functionality and fine tuning of the Notch pathway. In cancer, Notch is specifically involved in preserving self-renewal and amplification of cancer stem cells, supporting the formation, spread and recurrence of the tumor. As the function of Notch signaling is context dependent, we here provide an overview of its activity in a variety of tumors, focusing mostly on its role in the maintenance of the undifferentiated subset of cancer cells. Finally, we analyze the potential of molecules of the Notch pathway as diagnostic and therapeutic tools against the various cancers. MDPI 2020-08-11 /pmc/articles/PMC7463613/ /pubmed/32796631 http://dx.doi.org/10.3390/cells9081879 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Meisel, Christian T. Porcheri, Cristina Mitsiadis, Thimios A. Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression |
title | Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression |
title_full | Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression |
title_fullStr | Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression |
title_full_unstemmed | Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression |
title_short | Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression |
title_sort | cancer stem cells, quo vadis? the notch signaling pathway in tumor initiation and progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463613/ https://www.ncbi.nlm.nih.gov/pubmed/32796631 http://dx.doi.org/10.3390/cells9081879 |
work_keys_str_mv | AT meiselchristiant cancerstemcellsquovadisthenotchsignalingpathwayintumorinitiationandprogression AT porchericristina cancerstemcellsquovadisthenotchsignalingpathwayintumorinitiationandprogression AT mitsiadisthimiosa cancerstemcellsquovadisthenotchsignalingpathwayintumorinitiationandprogression |