A New Inhibitor of Tubulin Polymerization Kills Multiple Cancer Cell Types and Reveals p21-Mediated Mechanism Determining Cell Death after Mitotic Catastrophe

Induction of mitotic catastrophe through the disruption of microtubules is an established target in cancer therapy. However, the molecular mechanisms determining the mitotic catastrophe and the following apoptotic or non-apoptotic cell death remain poorly understood. Moreover, many existing drugs ta...

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Detalles Bibliográficos
Autores principales: Zdioruk, Mykola, Want, Andrew, Mietelska-Porowska, Anna, Laskowska-Kaszub, Katarzyna, Wojsiat, Joanna, Klejman, Agata, Użarowska, Ewelina, Koza, Paulina, Olejniczak, Sylwia, Pikul, Stanislaw, Konopka, Witold, Golab, Jakub, Wojda, Urszula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463620/
https://www.ncbi.nlm.nih.gov/pubmed/32759730
http://dx.doi.org/10.3390/cancers12082161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463620/
https://www.ncbi.nlm.nih.gov/pubmed/32759730
http://dx.doi.org/10.3390/cancers12082161

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