Predicted Hotspot Residues Involved in Allosteric Signal Transmission in Pro-Apoptotic Peptide—Mcl1 Complexes

Mcl1 is a primary member of the Bcl–2 family—anti–apoptotic proteins (AAP)—that is overexpressed in several cancer pathologies. The apoptotic regulation is mediated through the binding of pro-apoptotic peptides (PAPs) (e.g., Bak and Bid) at the canonical hydrophobic binding groove (CBG) of Mcl1. Alt...

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Detalles Bibliográficos
Autores principales: Marimuthu, Parthiban, Razzokov, Jamoliddin, Singaravelu, Kalaimathy, Bogaerts, Annemie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463671/
https://www.ncbi.nlm.nih.gov/pubmed/32731448
http://dx.doi.org/10.3390/biom10081114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463671/
https://www.ncbi.nlm.nih.gov/pubmed/32731448
http://dx.doi.org/10.3390/biom10081114

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