Cargando…

Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway

Repetitive intermittent hyperglycemia (RIH) is an independent risk factor for complications associated with type-2 diabetes (T2D). Glucose fluctuations commonly occur in T2D patients with poor glycemic control or following intensive therapy. Reducing blood glucose as well as glucose fluctuations is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Rashed, Fatema, Sindhu, Sardar, Arefanian, Hossein, Al Madhoun, Ashraf, Kochumon, Shihab, Thomas, Reeby, Al-Kandari, Sarah, Alghaith, Abdulwahab, Jacob, Texy, Al-Mulla, Fahd, Ahmad, Rasheed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463685/ https://www.ncbi.nlm.nih.gov/pubmed/32806763 http://dx.doi.org/10.3390/cells9081892

Ejemplares similares

Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity
por: Kochumon, Shihab, et al.
Publicado: (2022)

ROS/TNF-α Crosstalk Triggers the Expression of IL-8 and MCP-1 in Human Monocytic THP-1 Cells via the NF-κB and ERK1/2 Mediated Signaling
por: Akhter, Nadeem, et al.
Publicado: (2021)

Endoplasmic Reticulum Stress Promotes the Expression of TNF-α in THP-1 Cells by Mechanisms Involving ROS/CHOP/HIF-1α and MAPK/NF-κB Pathways
por: Akhter, Nadeem, et al.
Publicado: (2023)

Stearic Acid and TNF-α Co-Operatively Potentiate MIP-1α Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway
por: Kochumon, Shihab, et al.
Publicado: (2020)

Dectin-1 as a Potential Inflammatory Biomarker for Metabolic Inflammation in Adipose Tissue of Individuals with Obesity
por: Al Madhoun, Ashraf, et al.
Publicado: (2022)

Elevated adipose tissue associated IL-2 expression in obesity correlates with metabolic inflammation and insulin resistance
por: Kochumon, Shihab, et al.
Publicado: (2020)

Enhanced Adipose Expression of Interferon Regulatory Factor (IRF)-5 Associates with the Signatures of Metabolic Inflammation in Diabetic Obese Patients
por: Sindhu, Sardar, et al.
Publicado: (2020)

Increased Adipose Tissue Expression of IL-23 Associates with Inflammatory Markers in People with High LDL Cholesterol
por: Kochumon, Shihab, et al.
Publicado: (2022)

ACSL1 is a key regulator of inflammatory and macrophage foaming induced by short-term palmitate exposure or acute high-fat feeding
por: Al-Rashed, Fatema, et al.
Publicado: (2023)

MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress
por: Sindhu, Sardar, et al.
Publicado: (2020)

Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults
por: Al-Rashed, Fatema, et al.
Publicado: (2021)

Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation
por: Sindhu, Sardar, et al.
Publicado: (2019)

Adipose Tissue Steroid Receptor RNA Activator 1 (SRA1) Expression Is Associated with Obesity, Insulin Resistance, and Inflammation
por: Kochumon, Shihab, et al.
Publicado: (2021)

IFN-γ and LPS Induce Synergistic Expression of CCL2 in Monocytic Cells via H3K27 Acetylation
por: Akhter, Nadeem, et al.
Publicado: (2022)

TNF-α Increases IP-10 Expression in MCF-7 Breast Cancer Cells via Activation of the JNK/c-Jun Pathways
por: Kochumon, Shihab, et al.
Publicado: (2021)

Short Chain Fatty Acid Acetate Increases TNFα-Induced MCP-1 Production in Monocytic Cells via ACSL1/MAPK/NF-κB Axis
por: Al-Roub, Areej, et al.
Publicado: (2021)

Adipose Tissue Caveolin-1 Upregulation in Obesity Involves TNF-α/NF-κB Mediated Signaling
por: Al Madhoun, Ashraf, et al.
Publicado: (2023)

Increasing the Duration of Light Physical Activity Ameliorates Insulin Resistance Syndrome in Metabolically Healthy Obese Adults
por: Al-Rashed, Fatema, et al.
Publicado: (2020)

Adipose tissue gene expression of CXCL10 and CXCL11 modulates inflammatory markers in obesity: implications for metabolic inflammation and insulin resistance
por: Kochumon, Shihab, et al.
Publicado: (2020)

Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells
por: Al-Rashed, Fatema, et al.
Publicado: (2021)

IL-1β and TNFα Cooperativity in Regulating IL-6 Expression in Adipocytes Depends on CREB Binding and H3K14 Acetylation
por: Al-Roub, Areej, et al.
Publicado: (2021)

The Cooperative Induction of CCL4 in Human Monocytic Cells by TNF-α and Palmitate Requires MyD88 and Involves MAPK/NF-κB Signaling Pathways
por: Sindhu, Sardar, et al.
Publicado: (2019)

Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
por: Al-Rashed, Fatema, et al.
Publicado: (2021)

Increased adipose tissue expression of IL‐18R and its ligand IL‐18 associates with inflammation and insulin resistance in obesity
por: Ahmad, Rasheed, et al.
Publicado: (2017)

Caveolin-1 rs1997623 Single Nucleotide Polymorphism Creates a New Binding Site for the Early B-Cell Factor 1 That Instigates Adipose Tissue CAV1 Protein Overexpression
por: Al Madhoun, Ashraf, et al.
Publicado: (2022)

ACSL1 Regulates TNFα-Induced GM-CSF Production by Breast Cancer MDA-MB-231 Cells
por: Thomas, Reeby, et al.
Publicado: (2019)

LPS Induces GM-CSF Production by Breast Cancer MDA-MB-231 Cells via Long-Chain Acyl-CoA Synthetase 1
por: Al-Rashed, Fatema, et al.
Publicado: (2020)

Increased adipose tissue expression of TLR8 in obese individuals with or without type-2 diabetes: significance in metabolic inflammation
por: Ahmad, Rasheed, et al.
Publicado: (2016)

Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells
por: Al Madhoun, Ashraf, et al.
Publicado: (2021)

Dental Pulp Stem Cells Derived From Adult Human Third Molar Tooth: A Brief Review
por: Al Madhoun, Ashraf, et al.
Publicado: (2021)

Wharton’s jelly mesenchymal stem cells: a concise review of their secretome and prospective clinical applications
por: Drobiova, Hana, et al.
Publicado: (2023)

TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation
por: Hasan, Amal, et al.
Publicado: (2019)

TNFα induces matrix metalloproteinase-9 expression in monocytic cells through ACSL1/JNK/ERK/NF-kB signaling pathways
por: Al-Roub, Areej, et al.
Publicado: (2023)

Increased expression of the interleukin-1 receptor-associated kinase (IRAK)-1 is associated with adipose tissue inflammatory state in obesity
por: Ahmad, Rasheed, et al.
Publicado: (2015)

Correlation Profile of Suppression of Tumorigenicity 2 and/or Interleukin-33 with Biomarkers in the Adipose Tissue of Individuals with Different Metabolic States
por: Hasan, Amal, et al.
Publicado: (2020)

Low carbohydrate intake correlates with trends of insulin resistance and metabolic acidosis in healthy lean individuals
por: Al-Reshed, Fatema, et al.
Publicado: (2023)

Neutral sphingomyelinase‐2 and cardiometabolic diseases
por: Sindhu, Sardar, et al.
Publicado: (2021)

Cysteine dioxygenase type 1: A new player in adipose physiology and metabolic health
por: Sindhu, Sardar, et al.
Publicado: (2022)

Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology
por: Bitar, Milad S., et al.
Publicado: (2018)

TLR2 and AP-1/NF-kappaB are involved in the regulation of MMP-9 elicited by heat killed Listeria monocytogenes in human monocytic THP-1 cells
por: Shihab, Puthiyaveetil Kochumon, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5lah897bi542rtrp3ka39rvcrl