Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation

A series of novel hybrid 8-hydroxyquinoline-indole derivatives (7a–7e, 12a–12b and 18a–18h) were synthesized and screened for inhibitory activity against self-induced and metal-ion induced Aβ(1–42) aggregation as potential treatments for Alzheimer’s disease (AD). In vitro studies identified the most...

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Detalles Bibliográficos
Autores principales: Bowroju, Suresh K., Mainali, Nirjal, Ayyadevara, Srinivas, Penthala, Narsimha R., Krishnamachari, Sesha, Kakraba, Samuel, Reis, Robert J. Shmookler, Crooks, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463714/
https://www.ncbi.nlm.nih.gov/pubmed/32784464
http://dx.doi.org/10.3390/molecules25163610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463714/
https://www.ncbi.nlm.nih.gov/pubmed/32784464
http://dx.doi.org/10.3390/molecules25163610

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