Cargando…

Cancer Cell Acid Adaptation Gene Expression Response Is Correlated to Tumor-Specific Tissue Expression Profiles and Patient Survival

The acidic pH of the tumor microenvironment plays a critical role in driving cancer development toward a more aggressive phenotype, but the underlying mechanisms are unclear. To this end, phenotypic and genotypic changes induced by adaptation of cancer cells to chronic acidosis have been studied. Ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yao, Jiayi, Czaplinska, Dominika, Ialchina, Renata, Schnipper, Julie, Liu, Bin, Sandelin, Albin, Pedersen, Stine Falsig
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463722/ https://www.ncbi.nlm.nih.gov/pubmed/32764426 http://dx.doi.org/10.3390/cancers12082183

Ejemplares similares

Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness
por: Czaplinska, Dominika, et al.
Publicado: (2022)

Chronic acidosis rewires cancer cell metabolism through PPARα signaling
por: Rolver, Michala G., et al.
Publicado: (2023)

Acid Adaptation Promotes TRPC1 Plasma Membrane Localization Leading to Pancreatic Ductal Adenocarcinoma Cell Proliferation and Migration through Ca(2+) Entry and Interaction with PI3K/CaM
por: Schnipper, Julie, et al.
Publicado: (2022)

The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells
por: Giannuzzo, Andrea, et al.
Publicado: (2015)

Trafficking, localization and degradation of the Na(+),HCO(3)(−) co-transporter NBCn1 in kidney and breast epithelial cells
por: Olesen, Christina Wilkens, et al.
Publicado: (2018)

Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer
por: Rolver, Michala Gylling, et al.
Publicado: (2020)

The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca(2+)-Independent Manner
por: Schnipper, Julie, et al.
Publicado: (2022)

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer
por: Avnet, Sofia, et al.
Publicado: (2019)

Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
por: Lundø, Kathrine, et al.
Publicado: (2023)

Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures
por: Tornabene, Erica, et al.
Publicado: (2019)

Exploring hepatic hormone actions using a compilation of gene expression profiles
por: Ståhlberg, Nina, et al.
Publicado: (2005)

A step-by-step guide to analyzing CAGE data using R/Bioconductor
por: Thodberg, Malte, et al.
Publicado: (2019)

Transcriptional regulation of gene expression clusters in motor neurons following spinal cord injury
por: Ryge, Jesper, et al.
Publicado: (2010)

HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503
por: Gorbatenko, Andrej, et al.
Publicado: (2019)

Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment
por: Andersen, Anne Poder, et al.
Publicado: (2016)

LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival
por: Que, Yi, et al.
Publicado: (2019)

Publisher Correction to: TrancriptomeReconstructoR: data‑driven annotation of complex transcriptomes
por: Ivanov, Maxim, et al.
Publicado: (2021)

TrancriptomeReconstructoR: data-driven annotation of complex transcriptomes
por: Ivanov, Maxim, et al.
Publicado: (2021)

Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression
por: Garland, William, et al.
Publicado: (2022)

Discovery of Regulatory Elements is Improved by a Discriminatory Approach
por: Valen, Eivind, et al.
Publicado: (2009)

Aberrant CXCR4 and β-catenin expression in osteosarcoma correlates with patient survival
por: LU, YAO, et al.
Publicado: (2015)

The RNA exosome contributes to gene expression regulation during stem cell differentiation
por: Lloret-Llinares, Marta, et al.
Publicado: (2018)

The Vacuolar H(+) ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells
por: Flinck, Mette, et al.
Publicado: (2020)

Correlation between the expression of vegf and survival in osteosarcoma
por: Baptista, André Mathias, et al.
Publicado: (2014)

Multivariate Hawkes process models of the occurrence of regulatory elements
por: Carstensen, Lisbeth, et al.
Publicado: (2010)

Systematic Clustering of Transcription Start Site Landscapes
por: Zhao, Xiaobei, et al.
Publicado: (2011)

Computational identification of signals predictive for nuclear RNA exosome degradation pathway targeting
por: Wu, Mengjun, et al.
Publicado: (2022)

Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites
por: Schmidt, Søren F, et al.
Publicado: (2011)

PSMA Expression Correlates with Improved Overall Survival and VEGF Expression in Glioblastoma
por: Yuile, Alexander, et al.
Publicado: (2023)

Subgingival bacterial colonization profiles correlate with gingival tissue gene expression
por: Papapanou, Panos N, et al.
Publicado: (2009)

Dynamic Na(+)/H(+) exchanger 1 (NHE1) – calmodulin complexes of varying stoichiometry and structure regulate Ca(2+)-dependent NHE1 activation
por: Sjøgaard-Frich, Lise M, et al.
Publicado: (2021)

Aberrant DNMT3B7 expression correlates to tissue type, stage, and survival across cancers
por: Siddiqui, Safia, et al.
Publicado: (2018)

The RNA exosome shapes the expression of key protein-coding genes
por: Wu, Mengjun, et al.
Publicado: (2020)

The Na(+)/H(+) exchanger NHE1 is required for directional migration stimulated via PDGFR-α in the primary cilium
por: Schneider, Linda, et al.
Publicado: (2009)

spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data
por: Vitting-Seerup, Kristoffer, et al.
Publicado: (2014)

Expression of Ku70 correlates with survival in carcinoma of the cervix
por: Wilson, C R, et al.
Publicado: (2000)

Thrombomodulin expression in colorectal carcinoma is protective and correlates with survival
por: Hanly, A M, et al.
Publicado: (2006)

Identification of human silencers by correlating cross-tissue epigenetic profiles and gene expression
por: Huang, Di, et al.
Publicado: (2019)

Nuclear expression of XBP1s is correlated with breast cancer survival: a retrospective analysis based on tissue microarray
por: Wang, Mengyi, et al.
Publicado: (2017)

CAGEfightR: analysis of 5′-end data using R/Bioconductor
por: Thodberg, Malte, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_t265g7fkracbv28bd5bgcconlp