In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation,...

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Autores principales: Kontogiannidou, Eleni, Meikopoulos, Thomas, Gika, Helen, Panteris, Emmanuel, Vizirianakis, Ioannis S., Müllertz, Anette, Fatouros, Dimitrios G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463809/
https://www.ncbi.nlm.nih.gov/pubmed/32722400
http://dx.doi.org/10.3390/pharmaceutics12080699
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author Kontogiannidou, Eleni
Meikopoulos, Thomas
Gika, Helen
Panteris, Emmanuel
Vizirianakis, Ioannis S.
Müllertz, Anette
Fatouros, Dimitrios G.
author_facet Kontogiannidou, Eleni
Meikopoulos, Thomas
Gika, Helen
Panteris, Emmanuel
Vizirianakis, Ioannis S.
Müllertz, Anette
Fatouros, Dimitrios G.
author_sort Kontogiannidou, Eleni
collection PubMed
description Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. The presence of ionic liquids significantly enhanced the solubility of AmpB, exhibited a low toxicity and increased the transport of AmpB across Caco-2 cell monolayers. The combination of RTILs with a lipid formulation might be a promising strategy to improve the oral bioavailability of AmpB.
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spelling pubmed-74638092020-09-02 In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B Kontogiannidou, Eleni Meikopoulos, Thomas Gika, Helen Panteris, Emmanuel Vizirianakis, Ioannis S. Müllertz, Anette Fatouros, Dimitrios G. Pharmaceutics Article Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. The presence of ionic liquids significantly enhanced the solubility of AmpB, exhibited a low toxicity and increased the transport of AmpB across Caco-2 cell monolayers. The combination of RTILs with a lipid formulation might be a promising strategy to improve the oral bioavailability of AmpB. MDPI 2020-07-25 /pmc/articles/PMC7463809/ /pubmed/32722400 http://dx.doi.org/10.3390/pharmaceutics12080699 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kontogiannidou, Eleni
Meikopoulos, Thomas
Gika, Helen
Panteris, Emmanuel
Vizirianakis, Ioannis S.
Müllertz, Anette
Fatouros, Dimitrios G.
In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B
title In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B
title_full In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B
title_fullStr In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B
title_full_unstemmed In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B
title_short In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B
title_sort in vitro evaluation of self-nano-emulsifying drug delivery systems (snedds) containing room temperature ionic liquids (rtils) for the oral delivery of amphotericin b
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463809/
https://www.ncbi.nlm.nih.gov/pubmed/32722400
http://dx.doi.org/10.3390/pharmaceutics12080699
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