Protamine-2 Deficiency Initiates a Reactive Oxygen Species (ROS)-Mediated Destruction Cascade during Epididymal Sperm Maturation in Mice

Protamines are the safeguards of the paternal sperm genome. They replace most of the histones during spermiogenesis, resulting in DNA hypercondensation, thereby protecting its genome from environmental noxa. Impaired protamination has been linked to male infertility in mice and humans in many studie...

Descripción completa

Detalles Bibliográficos
Autores principales: Schneider, Simon, Shakeri, Farhad, Trötschel, Christian, Arévalo, Lena, Kruse, Alexander, Buness, Andreas, Poetsch, Ansgar, Steger, Klaus, Schorle, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463811/
https://www.ncbi.nlm.nih.gov/pubmed/32727081
http://dx.doi.org/10.3390/cells9081789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463811/
https://www.ncbi.nlm.nih.gov/pubmed/32727081
http://dx.doi.org/10.3390/cells9081789

Ejemplares similares