Cargando…

Adenosine Receptor Agonists Increase the Inhibition of Platelet Function by P2Y(12) Antagonists in a cAMP- and Calcium-Dependent Manner

We have shown previously that platelet activity can be lowered through the simultaneous inhibition of P2Y(12) receptor and activation of adenosine receptors (AR). This work explores this concept by testing the antiplatelet potential of nine AR agonists in combination with P2Y(12) receptor antagonist...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wolska, Nina, Kassassir, Hassan, Luzak, Boguslawa, Watala, Cezary, Rozalski, Marcin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464091/ https://www.ncbi.nlm.nih.gov/pubmed/32752089 http://dx.doi.org/10.3390/ph13080177

Ejemplares similares

Adenosine Receptor Agonists Exhibit Anti-Platelet Effects and the Potential to Overcome Resistance to P2Y(12) Receptor Antagonists
por: Wolska, Nina, et al.
Publicado: (2019)

SARS-CoV-2 Spike Protein and Neutralizing Anti-Spike Protein Antibodies Modulate Blood Platelet Function
por: Luzak, Boguslawa, et al.
Publicado: (2023)

Extract from Aronia melanocarpa fruits potentiates the inhibition of platelet aggregation in the presence of endothelial cells
por: Luzak, Boguslawa, et al.
Publicado: (2010)

Sample Preparation as a Critical Aspect of Blood Platelet Mitochondrial Respiration Measurements—The Impact of Platelet Activation on Mitochondrial Respiration
por: Siewiera, Karolina, et al.
Publicado: (2021)

Diabetes and Hyperglycemia Affect Platelet GPIIIa Expression: Effects on Adhesion Potential of Blood Platelets from Diabetic Patients under In Vitro Flow Conditions
por: Przygodzki, Tomasz, et al.
Publicado: (2020)

Blood Platelet Adenosine Receptors as Potential Targets for Anti-Platelet Therapy
por: Wolska, Nina, et al.
Publicado: (2019)

Potential Role of Mitochondria as Modulators of Blood Platelet Activation and Reactivity in Diabetes and Effect of Metformin on Blood Platelet Bioenergetics and Platelet Activation
por: Siewiera, Karolina, et al.
Publicado: (2022)

Platelet-Derived Procoagulant Microvesicles Are Elevated in Patients with Retinal Vein Occlusion (RVO)
por: Marcinkowska, Adrianna, et al.
Publicado: (2022)

Adenosine Receptor Agonist HE-NECA Enhances Antithrombotic Activities of Cangrelor and Prasugrel in vivo by Decreasing of Fibrinogen Density in Thrombus
por: Polak, Dawid, et al.
Publicado: (2021)

Extract from Ribes nigrum leaves in vitro activates nitric oxide synthase (eNOS) and increases CD39 expression in human endothelial cells
por: Luzak, Boguslawa, et al.
Publicado: (2014)

Fibrinogen Glycation and Presence of Glucose Impair Fibrin Polymerization—An In Vitro Study of Isolated Fibrinogen and Plasma from Patients with Diabetes Mellitus
por: Luzak, Boguslawa, et al.
Publicado: (2020)

Time-dependent interactions of blood platelets and cancer cells, accompanied by extramedullary hematopoiesis, lead to increased platelet activation and reactivity in a mouse orthotopic model of breast cancer – implications for pulmonary and liver metastasis
por: Kassassir, Hassan, et al.
Publicado: (2020)

The amino acid content in the daily diet of seniors negatively correlates with the degree of platelet aggregation in a sex- and agonist-specific manner
por: Karolczak, Kamil, et al.
Publicado: (2022)

CD39/NTPDase-1 expression and activity in human umbilical vein endothelial cells are differentially regulated by leaf extracts from Rubus caesius and Rubus idaeus
por: Dudzinska, Dominika, et al.
Publicado: (2014)

Astrocytic Calcium and cAMP in Neurodegenerative Diseases
por: Sobolczyk, Marta, et al.
Publicado: (2022)

Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions
por: Bednarek, Radosław, et al.
Publicado: (2023)

“cAMP Sponge”: A Buffer for Cyclic Adenosine 3′, 5′-Monophosphate
por: Lefkimmiatis, Konstantinos, et al.
Publicado: (2009)

Intravital Assessment of Blood Platelet Function. A Review of the Methodological Approaches with Examples of Studies of Selected Aspects of Blood Platelet Function
por: Polak, Dawid, et al.
Publicado: (2020)

New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP eﬄux and extracellular cAMP-adenosine pathway
por: Godinho, Rosely O., et al.
Publicado: (2015)

The Anti-Aggregative Potential of Resolvin E1 on Human Platelets
por: Szymańska, Patrycja, et al.
Publicado: (2023)

Synergy of cAMP and calcium signaling pathways in CFTR regulation
por: Bozoky, Zoltan, et al.
Publicado: (2017)

Platelets as Potential Non-Traditional Cardiovascular Risk Factor—Analysis Performed in Healthy Donors
por: Szymańska, Patrycja, et al.
Publicado: (2023)

Blood Platelets as an Important but Underrated Circulating Source of TGFβ
por: Karolczak, Kamil, et al.
Publicado: (2021)

The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP
por: McKean, Jenny S., et al.
Publicado: (2015)

Calcium and cAMP directly modulate the speed of the Drosophila circadian clock
por: Palacios-Muñoz, Angelina, et al.
Publicado: (2018)

Postsynaptic cAMP signalling regulates the antagonistic balance of Drosophila glutamate receptor subtypes
por: Zhao, Kai, et al.
Publicado: (2020)

Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung
por: Oldenburger, Anouk, et al.
Publicado: (2012)

Intracellular calcium and cAMP regulate directional pigment movements in teleost erythrophores
Publicado: (1994)

Stabilization of Acetylcholine Receptors by Exogenous ATP and Its Reversal by cAMP and Calcium
por: O'Malley, James P., et al.
Publicado: (1997)

A link of Ca(2+ )to cAMP oscillations in Dictyostelium: the calmodulin antagonist W-7 potentiates cAMP relay and transiently inhibits the acidic Ca(2+)-store
por: Malchow, Dieter, et al.
Publicado: (2004)

Quantification of the Blood Platelet Reactivity in the ADP-Induced Model of Non-Lethal Pulmonary Thromboembolism in Mice with the Use of Laser Doppler Flowmetry
por: Przygodzki, Tomasz, et al.
Publicado: (2016)

cAMP crosses junctions
por: Bashyam, Hema
Publicado: (2007)

Mitochondrial cAMP signaling
por: Zhang, Fan, et al.
Publicado: (2016)

Extracellular cAMP-Adenosine Pathway Signaling: A Potential Therapeutic Target in Chronic Inflammatory Airway Diseases
por: Pacini, Enio Setsuo Arakaki, et al.
Publicado: (2022)

Differential regulation of platelet inhibition by cGMP- and cAMP-dependent protein kinases
por: Subramanian, Hariharan, et al.
Publicado: (2013)

The Spatiotemporal Regulation of cAMP Signaling in Blood Platelets—Old Friends and New Players
por: Raslan, Zaher, et al.
Publicado: (2015)

Helicobacter pylori Induces miR-155 in T Cells in a cAMP-Foxp3-Dependent Manner
por: Fassi Fehri, Lina, et al.
Publicado: (2010)

cAMP binds to closed, inactivated, and open sea urchin HCN channels in a state-dependent manner
por: Idikuda, Vinay, et al.
Publicado: (2019)

The seeming paradox of adenosine receptors as targets for the treatment of Alzheimer's disease: agonists or antagonists?
por: Marzagalli, Rubina, et al.
Publicado: (2015)

Sensitivity of GBM cells to cAMP agonist-mediated apoptosis correlates with CD44 expression and agonist resistance with MAPK signaling
por: Daniel, Paul M, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qvrfgl4kfmpdoipa6hmrdii385