Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver

In the liver, energy homeostasis is mainly regulated by mechanistic target of rapamycin (mTOR) signalling, which influences relevant metabolic pathways, including lipid metabolism. However, the Hedgehog (Hh) pathway is one of the newly identified drivers of hepatic lipid metabolism. Although the lin...

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Detalles Bibliográficos
Autores principales: Spormann, Luise, Rennert, Christiane, Kolbe, Erik, Ott, Fritzi, Lossius, Carolin, Lehmann, Robert, Gebhardt, Rolf, Berg, Thomas, Matz-Soja, Madlen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464279/
https://www.ncbi.nlm.nih.gov/pubmed/32751882
http://dx.doi.org/10.3390/cells9081817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464279/
https://www.ncbi.nlm.nih.gov/pubmed/32751882
http://dx.doi.org/10.3390/cells9081817

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