The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

The intrinsically disordered protein α-synuclein (aSN) is, in its fibrillated state, the main component of Lewy bodies—hallmarks of Parkinson’s disease. Additional Lewy body components include glycosaminoglycans, including heparan sulfate proteoglycans. In humans, heparan sulfate has, in an age-depe...

Descripción completa

Detalles Bibliográficos
Autores principales: Skaanning, Line K., Santoro, Angelo, Skamris, Thomas, Martinsen, Jacob Hertz, D’Ursi, Anna Maria, Bucciarelli, Saskia, Vestergaard, Bente, Bugge, Katrine, Langkilde, Annette Eva, Kragelund, Birthe B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464290/
https://www.ncbi.nlm.nih.gov/pubmed/32824376
http://dx.doi.org/10.3390/biom10081192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464290/
https://www.ncbi.nlm.nih.gov/pubmed/32824376
http://dx.doi.org/10.3390/biom10081192

Ejemplares similares