Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma

Apoptotic resistance remains a hallmark of glioblastoma (GBM), the most common primary brain tumor in adults, and a better understanding of this process may result in more efficient treatments. By utilizing chromatin immunoprecipitation with next-generation sequencing (CHIP-seq), we discovered that...

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Detalles Bibliográficos
Autores principales: Shang, Enyuan, Nguyen, Trang T. T., Shu, Chang, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464325/
https://www.ncbi.nlm.nih.gov/pubmed/32752193
http://dx.doi.org/10.3390/cancers12082137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464325/
https://www.ncbi.nlm.nih.gov/pubmed/32752193
http://dx.doi.org/10.3390/cancers12082137

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