Progestogens Are Metabolized by the Gut Microbiota: Implications for Colonic Drug Delivery

Following oral administration, the bioavailability of progestogens is very low and highly variable, in part due to metabolism by cytochrome P450 enzymes found in the mucosa of the small intestine. Conversely, the mucosa in the colon contains much lower levels of cytochrome P450 enzymes, thus, coloni...

Descripción completa

Detalles Bibliográficos
Autores principales: Coombes, Zoe, Yadav, Vipul, E. McCoubrey, Laura, Freire, Cristina, W. Basit, Abdul, Conlan, R. Steven, Gonzalez, Deyarina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464400/
https://www.ncbi.nlm.nih.gov/pubmed/32806503
http://dx.doi.org/10.3390/pharmaceutics12080760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464400/
https://www.ncbi.nlm.nih.gov/pubmed/32806503
http://dx.doi.org/10.3390/pharmaceutics12080760

Ejemplares similares