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Progestogens Are Metabolized by the Gut Microbiota: Implications for Colonic Drug Delivery
Following oral administration, the bioavailability of progestogens is very low and highly variable, in part due to metabolism by cytochrome P450 enzymes found in the mucosa of the small intestine. Conversely, the mucosa in the colon contains much lower levels of cytochrome P450 enzymes, thus, coloni...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464400/ https://www.ncbi.nlm.nih.gov/pubmed/32806503 http://dx.doi.org/10.3390/pharmaceutics12080760 |