Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction

Toll-like receptor 4 (TLR4) contributes to the pathogenesis of coronary ischemia/reperfusion (IR). To test whether the new TLR4 antagonist, ApTOLL, may prevent coronary IR damage, we administered 0.078 mg/kg ApTOLL or Placebo in pigs subjected to IR, analyzing the levels of cardiac troponins, matrix...

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Detalles Bibliográficos
Autores principales: Ramirez-Carracedo, Rafael, Tesoro, Laura, Hernandez, Ignacio, Diez-Mata, Javier, Piñeiro, David, Hernandez-Jimenez, Macarena, Zamorano, Jose Luis, Zaragoza, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464507/
https://www.ncbi.nlm.nih.gov/pubmed/32784904
http://dx.doi.org/10.3390/biom10081167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464507/
https://www.ncbi.nlm.nih.gov/pubmed/32784904
http://dx.doi.org/10.3390/biom10081167

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