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Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction

Toll-like receptor 4 (TLR4) contributes to the pathogenesis of coronary ischemia/reperfusion (IR). To test whether the new TLR4 antagonist, ApTOLL, may prevent coronary IR damage, we administered 0.078 mg/kg ApTOLL or Placebo in pigs subjected to IR, analyzing the levels of cardiac troponins, matrix...

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Detalles Bibliográficos
Autores principales:	Ramirez-Carracedo, Rafael, Tesoro, Laura, Hernandez, Ignacio, Diez-Mata, Javier, Piñeiro, David, Hernandez-Jimenez, Macarena, Zamorano, Jose Luis, Zaragoza, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464507/ https://www.ncbi.nlm.nih.gov/pubmed/32784904 http://dx.doi.org/10.3390/biom10081167

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