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Impact of Short-Term Hypoxia on Sirtuins as Regulatory Elements in HUVECs

Background: Sirtuins (SIRT) are NAD(+)-dependent deacetylases that are involved in stress response, antioxidative defense, and longevity via posttranslational modifications. SIRT1 directly activates nitric oxide synthase (NOS). Aging is associated with a reduced sirtuin function and reduction of the...

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Detalles Bibliográficos
Autores principales: Pecher, Simone Johanna, Potthast, Arne Björn, von Versen-Höynck, Frauke, Das, Anibh Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464651/
https://www.ncbi.nlm.nih.gov/pubmed/32796661
http://dx.doi.org/10.3390/jcm9082604