Calcium Export from Neurons and Multi-Kinase Signaling Cascades Contribute to Ouabain Neuroprotection in Hyperhomocysteinemia

Pathological homocysteine (HCY) accumulation in the human plasma, known as hyperhomocysteinemia, exacerbates neurodegenerative diseases because, in the brain, this amino acid acts as a persistent N-methyl-d-aspartate receptor agonist. We studied the effects of 0.1–1 nM ouabain on intracellular Ca(2+...

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Detalles Bibliográficos
Autores principales: Ivanova, Maria A., Kokorina, Arina D., Timofeeva, Polina D., Karelina, Tatiana V., Abushik, Polina A., Stepanenko, Julia D., Sibarov, Dmitry A., Antonov, Sergei M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464744/
https://www.ncbi.nlm.nih.gov/pubmed/32722349
http://dx.doi.org/10.3390/biom10081104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464744/
https://www.ncbi.nlm.nih.gov/pubmed/32722349
http://dx.doi.org/10.3390/biom10081104

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