Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action

Lubiprostone, a 20-carbon synthetic fatty acid used for the treatment of constipation, is thought to act through an action on Cl(−) channel ClC-2. Short chain fatty acids (SCFAs) are produced and absorbed in the distal intestine. We explore whether SCFAs affect ClC-2, re-examine a possible direct ef...

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Detalles Bibliográficos
Autores principales: Catalán, Marcelo A., Julio-Kalajzić, Francisca, Niemeyer, María Isabel, Cid, Luis Pablo, Sepúlveda, Francisco V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464869/
https://www.ncbi.nlm.nih.gov/pubmed/32722648
http://dx.doi.org/10.3390/cells9081781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464869/
https://www.ncbi.nlm.nih.gov/pubmed/32722648
http://dx.doi.org/10.3390/cells9081781

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