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Pro-Oxidant Activity of an ALS-Linked SOD1 Mutant in Zn-Deficient Form
Cu, Zn superoxide dismutase (SOD1) is a representative antioxidant enzyme that catalyzes dismutation of reactive oxygen species in cells. However, (E,E)-SOD1 mutants in which both copper and zinc ions were deleted exhibit pro-oxidant activity, contrary to their antioxidant nature, at physiological t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464938/ https://www.ncbi.nlm.nih.gov/pubmed/32784718 http://dx.doi.org/10.3390/molecules25163600 |