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Pro-Oxidant Activity of an ALS-Linked SOD1 Mutant in Zn-Deficient Form

Cu, Zn superoxide dismutase (SOD1) is a representative antioxidant enzyme that catalyzes dismutation of reactive oxygen species in cells. However, (E,E)-SOD1 mutants in which both copper and zinc ions were deleted exhibit pro-oxidant activity, contrary to their antioxidant nature, at physiological t...

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Detalles Bibliográficos
Autores principales:	Nagao, Chise, Kuroi, Kunisato, Wakabayashi, Taiyu, Nakabayashi, Takakazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464938/ https://www.ncbi.nlm.nih.gov/pubmed/32784718 http://dx.doi.org/10.3390/molecules25163600

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