In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase

Fluoropyrimidine drugs (FPs), including 5-fluorouracil, tegafur, capecitabine, and doxifluridine, are among the most widely used anticancer agents in the treatment of solid tumors. However, severe toxicity occurs in approximately 30% of patients following FP administration, emphasizing the importanc...

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Detalles Bibliográficos
Autores principales: Hishinuma, Eiji, Gutiérrez Rico, Evelyn, Hiratsuka, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464968/
https://www.ncbi.nlm.nih.gov/pubmed/32707991
http://dx.doi.org/10.3390/jcm9082342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464968/
https://www.ncbi.nlm.nih.gov/pubmed/32707991
http://dx.doi.org/10.3390/jcm9082342

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