Cargando…

Comprehensive Genomic Analysis Reveals the Prognostic Role of LRRK2 Copy-Number Variations in Human Malignancies

Genetic alterations of leucine-rich repeat kinase 2 (LRRK2), one of the most important contributors to familial Parkinson’s disease (PD), have been hypothesized to play a role in cancer development due to demographical and preclinical data. Here, we sought to define the prevalence and prognostic sig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lopez, Gianluca, Lazzeri, Giulia, Rappa, Alessandra, Isimbaldi, Giuseppe, Cribiù, Fulvia Milena, Guerini-Rocco, Elena, Ferrero, Stefano, Vaira, Valentina, Di Fonzo, Alessio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465025/ https://www.ncbi.nlm.nih.gov/pubmed/32722212 http://dx.doi.org/10.3390/genes11080846

Ejemplares similares

SCARB1 downregulation in adrenal insufficiency with Allgrove syndrome
por: Bitetto, Giacomo, et al.
Publicado: (2023)

The Contrasting Role of p16(Ink4A) Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations
por: Fusco, Nicola, et al.
Publicado: (2015)

Comprehensively benchmarking applications for detecting copy number variation
por: Zhang, Le, et al.
Publicado: (2019)

Inter-tumor genomic heterogeneity of breast cancers: comprehensive genomic profile of primary early breast cancers and relapses
por: Fumagalli, Caterina, et al.
Publicado: (2020)

Correction: Comprehensively benchmarking applications for detecting copy number variation
por: Zhang, Le, et al.
Publicado: (2019)

aCNViewer: Comprehensive genome-wide visualization of absolute copy number and copy neutral variations
por: Renault, Victor, et al.
Publicado: (2017)

Short-term Oral Antibiotics Treatment Promotes Inflammatory Activation of Colonic Invariant Natural Killer T and Conventional CD4(+) T Cells
por: Burrello, Claudia, et al.
Publicado: (2018)

Comprehensive copy number profiles of breast cancer cell model genomes
por: Shadeo, Ashleen, et al.
Publicado: (2006)

A comprehensive analysis of copy number variations in diverse apple populations
por: Xu, Jinsheng, et al.
Publicado: (2023)

The Prevalence and Clinical Impact of Adenomyosis in Pregnancy-Related Hysterectomy
por: Orsi, Michele, et al.
Publicado: (2022)

Unproductive Effects of ALK Gene Amplification and Copy Number Gain in Non-Small-Cell Lung Cancer. ALK Gene Amplification and Copy Gain in NSCLC
por: Zito Marino, Federica, et al.
Publicado: (2020)

Editorial: Copy Number Variants in Neurological Disorder
por: Gentile, Giulia, et al.
Publicado: (2018)

New Copy Number Variations in Schizophrenia
por: Magri, Chiara, et al.
Publicado: (2010)

A comprehensive survey of copy number variation in 18 diverse pig populations and identification of candidate copy number variable genes associated with complex traits
por: Chen, Congying, et al.
Publicado: (2012)

CNVannotator: A Comprehensive Annotation Server for Copy Number Variation in the Human Genome
por: Zhao, Min, et al.
Publicado: (2013)

A comprehensive analysis of copy number variation in a Turkish dementia cohort
por: Dehghani, Nadia, et al.
Publicado: (2021)

Gliosarcoma: The Distinct Genomic Alterations Identified by Comprehensive Analysis of Copy Number Variations
por: Cheng, Chuan-dong, et al.
Publicado: (2022)

A comprehensive overview of SMN and NAIP copy numbers in Iranian SMA patients
por: Savad, Shahram, et al.
Publicado: (2023)

Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice
por: Giesert, Florian, et al.
Publicado: (2013)

Copy-number-variation and copy-number-alteration region detection by cumulative plots
por: Li, Wentian, et al.
Publicado: (2009)

Interactive analysis of large cancer copy number studies with Copy Number Explorer
por: Newman, Scott
Publicado: (2015)

Histological characterization of placenta in COVID19 pregnant women
por: Cribiù, Fulvia Milena, et al.
Publicado: (2020)

In-house testing for homologous recombination repair deficiency (HRD) testing in ovarian carcinoma: a feasibility study comparing AmoyDx HRD Focus panel with Myriad myChoiceCDx assay
por: Fumagalli, Caterina, et al.
Publicado: (2022)

Osteoclast-like stromal giant cells in breast cancer likely belong to the spectrum of immunosuppressive tumor-associated macrophages
por: Sajjadi, Elham, et al.
Publicado: (2022)

Targeting the Autonomic Nervous System for Risk Stratification, Outcome Prediction and Neuromodulation in Ischemic Stroke
por: Carandina, Angelica, et al.
Publicado: (2021)

LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease
por: Kedariti, Maria, et al.
Publicado: (2022)

Comprehensive Assessment of Copy Number Alterations Uncovers Recurrent AIFM3 and DLK1 Copy Gain in Medullary Thyroid Carcinoma
por: Araujo, Aline Neves, et al.
Publicado: (2021)

Plasmodium copy number variation scan: gene copy numbers evaluation in haploid genomes
por: Beghain, Johann, et al.
Publicado: (2016)

Comprehensive Analysis of Copy Number Variations in Kidney Cancer by Single-Cell Exome Sequencing
por: Zhou, Wenyang, et al.
Publicado: (2020)

Comprehensive analysis of somatic copy number alterations in clear cell renal cell carcinoma
por: Tsuyukubo, Takashi, et al.
Publicado: (2020)

Comprehensive identification and characterization of somatic copy number alterations in triple-negative breast cancer
por: Li, Zaibing, et al.
Publicado: (2019)

Comprehensive Evaluation of Non-invasive Prenatal Screening to Detect Fetal Copy Number Variations
por: Wang, Jing, et al.
Publicado: (2021)

Comprehensive Somatic Copy Number Analysis Using Aqueous Humor Liquid Biopsy for Retinoblastoma
por: Kim, Mary E., et al.
Publicado: (2021)

Dynamic and redundant regulation of LRRK2 and LRRK1 expression
por: Biskup, Saskia, et al.
Publicado: (2007)

Copy number variations and cancer
por: Shlien, Adam, et al.
Publicado: (2009)

Copy number variations and stroke
por: Colaianni, Valeria, et al.
Publicado: (2016)

Copy Number Variations and Schizophrenia
por: Szecówka, Kamila, et al.
Publicado: (2022)

Copy Number Variation and Osteoporosis
por: Lovšin, Nika
Publicado: (2023)

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
por: Malik, Asad U., et al.
Publicado: (2021)

Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells
por: Burrello, Claudia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ji56mvblql095rvqhsq51f8lna