Stable Longitudinal Methylation Levels at the CpG Sites Flanking the CTG Repeat of DMPK in Patients with Myotonic Dystrophy Type 1

Myotonic dystrophy type 1 (DM1) is an autosomal dominant multisystem disorder mainly characterized by gradual muscle loss, weakness, and delayed relaxation after muscle contraction. It is caused by an expanded CTG repeat in the 3′ UTR of DMPK, which is transcribed into a toxic gain-of-function mRNA...

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Detalles Bibliográficos
Autores principales: Hildonen, Mathis, Knak, Kirsten Lykke, Dunø, Morten, Vissing, John, Tümer, Zeynep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465187/
https://www.ncbi.nlm.nih.gov/pubmed/32823742
http://dx.doi.org/10.3390/genes11080936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465187/
https://www.ncbi.nlm.nih.gov/pubmed/32823742
http://dx.doi.org/10.3390/genes11080936

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