Development of [(18)F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis

Insufficient apoptosis is a recognised hallmark of cancer. A strategy to quantitatively measure apoptosis in vivo would be of immense value in both drug discovery and routine patient management. The first irreversible step in the apoptosis cascade is activation of the “executioner” caspase-3 enzyme...

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Autores principales: García-Argüello, Segundo Francisco, Lopez-Lorenzo, Beatriz, Cornelissen, Bart, Smith, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465189/
https://www.ncbi.nlm.nih.gov/pubmed/32781531
http://dx.doi.org/10.3390/cancers12082191
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author García-Argüello, Segundo Francisco
Lopez-Lorenzo, Beatriz
Cornelissen, Bart
Smith, Graham
author_facet García-Argüello, Segundo Francisco
Lopez-Lorenzo, Beatriz
Cornelissen, Bart
Smith, Graham
author_sort García-Argüello, Segundo Francisco
collection PubMed
description Insufficient apoptosis is a recognised hallmark of cancer. A strategy to quantitatively measure apoptosis in vivo would be of immense value in both drug discovery and routine patient management. The first irreversible step in the apoptosis cascade is activation of the “executioner” caspase-3 enzyme to commence cleavage of key structural proteins. One strategy to measure caspase-3 activity is Positron Emission Tomography using isatin-5-sulfonamide radiotracers. One such radiotracer is [(18)F]ICMT-11, which has progressed to clinical application. This review summarises the design and development process for [(18)F]ICMT-11, suggesting potential avenues for further innovation.
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spelling pubmed-74651892020-09-04 Development of [(18)F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis García-Argüello, Segundo Francisco Lopez-Lorenzo, Beatriz Cornelissen, Bart Smith, Graham Cancers (Basel) Review Insufficient apoptosis is a recognised hallmark of cancer. A strategy to quantitatively measure apoptosis in vivo would be of immense value in both drug discovery and routine patient management. The first irreversible step in the apoptosis cascade is activation of the “executioner” caspase-3 enzyme to commence cleavage of key structural proteins. One strategy to measure caspase-3 activity is Positron Emission Tomography using isatin-5-sulfonamide radiotracers. One such radiotracer is [(18)F]ICMT-11, which has progressed to clinical application. This review summarises the design and development process for [(18)F]ICMT-11, suggesting potential avenues for further innovation. MDPI 2020-08-06 /pmc/articles/PMC7465189/ /pubmed/32781531 http://dx.doi.org/10.3390/cancers12082191 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
García-Argüello, Segundo Francisco
Lopez-Lorenzo, Beatriz
Cornelissen, Bart
Smith, Graham
Development of [(18)F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis
title Development of [(18)F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis
title_full Development of [(18)F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis
title_fullStr Development of [(18)F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis
title_full_unstemmed Development of [(18)F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis
title_short Development of [(18)F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis
title_sort development of [(18)f]icmt-11 for imaging caspase-3/7 activity during therapy-induced apoptosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465189/
https://www.ncbi.nlm.nih.gov/pubmed/32781531
http://dx.doi.org/10.3390/cancers12082191
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