Diabetes Upregulates Oxidative Stress and Downregulates Cardiac Protection to Exacerbate Myocardial Ischemia/Reperfusion Injury in Rats

Diabetes exacerbates myocardial ischemia/reperfusion (IR) injury by incompletely understood mechanisms. We explored whether diabetes diminished BAG3/Bcl-2/Nrf-2/HO-1-mediated cardioprotection and overproduced oxidative stress contributing to exaggerated IR injury. Streptozotocin-induced diabetes enh...

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Detalles Bibliográficos
Autores principales: Chien, Chen-Yen, Wen, Ting-Jui, Cheng, Yu-Hsiuan, Tsai, Yi-Ting, Chiang, Chih-Yao, Chien, Chiang-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465304/
https://www.ncbi.nlm.nih.gov/pubmed/32751309
http://dx.doi.org/10.3390/antiox9080679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465304/
https://www.ncbi.nlm.nih.gov/pubmed/32751309
http://dx.doi.org/10.3390/antiox9080679

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