Cargando…

Diabetes Upregulates Oxidative Stress and Downregulates Cardiac Protection to Exacerbate Myocardial Ischemia/Reperfusion Injury in Rats

Diabetes exacerbates myocardial ischemia/reperfusion (IR) injury by incompletely understood mechanisms. We explored whether diabetes diminished BAG3/Bcl-2/Nrf-2/HO-1-mediated cardioprotection and overproduced oxidative stress contributing to exaggerated IR injury. Streptozotocin-induced diabetes enh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chien, Chen-Yen, Wen, Ting-Jui, Cheng, Yu-Hsiuan, Tsai, Yi-Ting, Chiang, Chih-Yao, Chien, Chiang-Ting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465304/ https://www.ncbi.nlm.nih.gov/pubmed/32751309 http://dx.doi.org/10.3390/antiox9080679

Ejemplares similares

Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion induced apoptosis and autophagy in the rat
por: Wu, Hsing-Hui, et al.
Publicado: (2009)

Deep-Sea Water Containing Selenium Provides Intestinal Protection against Duodenal Ulcers through the Upregulation of Bcl-2 and Thioredoxin Reductase 1
por: Yang, Chih-Ching, et al.
Publicado: (2014)

Anti-IL-20 Antibody Protects against Ischemia/Reperfusion-Impaired Myocardial Function through Modulation of Oxidative Injuries, Inflammation and Cardiac Remodeling
por: Tsai, Kun-Ling, et al.
Publicado: (2021)

Downregulation of apoptotic repressor AVEN exacerbates cardiac injury after myocardial infarction
por: Yu, Peng, et al.
Publicado: (2023)

Sulforaphane Improves Ischemia-Induced Detrusor Overactivity by Downregulating the Enhancement of Associated Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Rat Bladder
por: Tai, Huai-Ching, et al.
Publicado: (2016)

Intrarenal Arterial Transplantation of Dexmedetomidine Preconditioning Adipose Stem-Cell-Derived Microvesicles Confers Further Therapeutic Potential to Attenuate Renal Ischemia/Reperfusion Injury through miR-122-5p/Erythropoietin/Apoptosis Axis
por: Cheng, Yu-Hsuan, et al.
Publicado: (2022)

Protective Effect of CXCR4 Antagonist DBPR807 against Ischemia-Reperfusion Injury in a Rat and Porcine Model of Myocardial Infarction: Potential Adjunctive Therapy for Percutaneous Coronary Intervention
por: Yeh, Kai-Chia, et al.
Publicado: (2022)

Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Damage in Diabetic Rats
por: Chung, Cheng-Hsun, et al.
Publicado: (2022)

Retraction Note: Sulforaphane Improves Ischemia-Induced Detrusor Overactivity by Downregulating the Enhancement of Associated Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Rat Bladder
por: Tai, Huai-Ching, et al.
Publicado: (2023)

Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in Mice
por: Yang, Chih-Ching, et al.
Publicado: (2021)

Hyperleptinemia results in systemic inflammation and the exacerbation of ischemia-reperfusion myocardial injury
por: Polyakova, Ekaterina A., et al.
Publicado: (2021)

Paeonol Protects Against Myocardial Ischemia/Reperfusion-Induced Injury by Mediating Apoptosis and Autophagy Crosstalk
por: Tsai, Chin-Feng, et al.
Publicado: (2021)

Xanthohumol Protects the Rat Myocardium against Ischemia/Reperfusion Injury-Induced Ferroptosis
por: Lin, Jian-Hong, et al.
Publicado: (2022)

Hypoxic mesenchymal stem cells ameliorate acute kidney ischemia-reperfusion injury via enhancing renal tubular autophagy
por: Tseng, Wei-Cheng, et al.
Publicado: (2021)

Protective Role of AMP-Activated Protein Kinase-Evoked Autophagy on an In Vitro Model of Ischemia/Reperfusion-Induced Renal Tubular Cell Injury
por: Wang, Li-Ting, et al.
Publicado: (2013)

Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKKβ to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma
por: Yen, Chia-Jui, et al.
Publicado: (2012)

Role of Endothelial Cells in Myocardial Ischemia-Reperfusion Injury
por: Singhal, Arun K., et al.
Publicado: (2010)

Nuciferine improves cardiac function in mice subjected to myocardial ischemia/reperfusion injury by upregulating PPAR-γ
por: Li, Ruisha, et al.
Publicado: (2023)

Gossypol Acetic Acid Attenuates Cardiac Ischemia/Reperfusion Injury in Rats via an Antiferroptotic Mechanism
por: Lin, Jian-Hong, et al.
Publicado: (2021)

GSK3β Exacerbates Myocardial Ischemia/Reperfusion Injury by Inhibiting Myc
por: Wen, Cong, et al.
Publicado: (2022)

Xenogeneic and Allogeneic Mesenchymal Stem Cells Effectively Protect the Lung Against Ischemia-reperfusion Injury Through Downregulating the Inflammatory, Oxidative Stress, and Autophagic Signaling Pathways in Rat
por: Lin, Kun-Chen, et al.
Publicado: (2020)

Calpain: the regulatory point of myocardial ischemia-reperfusion injury
por: Liu, Guo-Yang, et al.
Publicado: (2023)

Protective role of silibinin against myocardial ischemia/reperfusion injury-induced cardiac dysfunction
por: Chen, Yi-He, et al.
Publicado: (2020)

Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury
por: Qian, Weidong, et al.
Publicado: (2014)

Protective approaches against myocardial ischemia reperfusion injury
por: Li, Xianchi, et al.
Publicado: (2016)

Protective effect of celastrol on myocardial ischemia–reperfusion injury
por: Li, Xiaoyan, et al.
Publicado: (2017)

Protective role of fibrates in cardiac ischemia/reperfusion
por: Singh, G., et al.
Publicado: (2012)

Upregulated ATF6 contributes to chronic intermittent hypoxia-afforded protection against myocardial ischemia/reperfusion injury
por: JIA, WEIKUN, et al.
Publicado: (2016)

Myocardial ischemia reperfusion injury is alleviated by curcumin-peptide hydrogel via upregulating autophagy and protecting mitochondrial function
por: Liao, Chi-Lin, et al.
Publicado: (2021)

Restoration of HDAC1 Enzymatic Activity after Stroke Protects Neurons from Ischemia/Reperfusion Damage and Attenuates Behavioral Deficits in Rats
por: Chen, Jui-Sheng, et al.
Publicado: (2021)

Loss of Rbl2 (Retinoblastoma‐Like 2) Exacerbates Myocardial Ischemia/Reperfusion Injury
por: Chen, Jingrui, et al.
Publicado: (2022)

Downregulation of microRNA-23a confers protection against myocardial ischemia/reperfusion injury by upregulating tissue factor pathway inhibitor 2 following luteolin pretreatment in rats
por: Luo, Yuanyuan, et al.
Publicado: (2023)

miR-1 Exacerbates Cardiac Ischemia-Reperfusion Injury in Mouse Models
por: Pan, Zhenwei, et al.
Publicado: (2012)

Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts
por: Alexander, Emily Davis, et al.
Publicado: (2022)

Urocortin Treatment Improves Acute Hemodynamic Instability and Reduces Myocardial Damage in Post-Cardiac Arrest Myocardial Dysfunction
por: Huang, Chien-Hua, et al.
Publicado: (2016)

Cardiac Microvascular Barrier Function Mediates the Protection of Tongxinluo against Myocardial Ischemia/Reperfusion Injury
por: Qi, Kang, et al.
Publicado: (2015)

Adipose-Derived Stem Cells and Their Derived Microvesicles Ameliorate Detrusor Overactivity Secondary to Bilateral Partial Iliac Arterial Occlusion-Induced Bladder Ischemia
por: Chiang, Bing-Juin, et al.
Publicado: (2021)

Role of Opioid Receptors Signaling in Remote Electrostimulation - Induced Protection against Ischemia/Reperfusion Injury in Rat Hearts
por: Tsai, Hsin-Ju, et al.
Publicado: (2015)

Protective effects of GV1001 on myocardial ischemia-reperfusion injury
por: Chang, Ji-Eun, et al.
Publicado: (2017)

Protective effect of morin on myocardial ischemia-reperfusion injury in rats
por: Liu, Shuang, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ijbge952khrsi4bpgf2mdh0eo6