Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation

Non-small-cell lung cancer (NSCLC) cell lines vary in their sensitivity to glutaminase inhibitors, so it is important to identify the metabolic assets underling their efficacy in cancer cells. Even though specific genetic lesions such as in KRAS and LKB1 have been associated with reliance on glutami...

Descripción completa

Detalles Bibliográficos
Autores principales: Caiola, Elisa, Colombo, Marika, Sestito, Giovanna, Lupi, Monica, Marabese, Mirko, Pastorelli, Roberta, Broggini, Massimo, Brunelli, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465377/
https://www.ncbi.nlm.nih.gov/pubmed/32718002
http://dx.doi.org/10.3390/cells9081766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465377/
https://www.ncbi.nlm.nih.gov/pubmed/32718002
http://dx.doi.org/10.3390/cells9081766

Ejemplares similares