Brain-Specific Serine-47 Modification of Cytochrome c Regulates Cytochrome c Oxidase Activity Attenuating ROS Production and Cell Death: Implications for Ischemia/Reperfusion Injury and Akt Signaling

We previously reported that serine-47 (S47) phosphorylation of cytochrome c (Cytc) in the brain results in lower cytochrome c oxidase (COX) activity and caspase-3 activity in vitro. We here analyze the effect of S47 modification in fibroblast cell lines stably expressing S47E phosphomimetic Cytc, un...

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Detalles Bibliográficos
Autores principales: Kalpage, Hasini A., Wan, Junmei, Morse, Paul T., Lee, Icksoo, Hüttemann, Maik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465522/
https://www.ncbi.nlm.nih.gov/pubmed/32781572
http://dx.doi.org/10.3390/cells9081843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465522/
https://www.ncbi.nlm.nih.gov/pubmed/32781572
http://dx.doi.org/10.3390/cells9081843

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