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Brain-Specific Serine-47 Modification of Cytochrome c Regulates Cytochrome c Oxidase Activity Attenuating ROS Production and Cell Death: Implications for Ischemia/Reperfusion Injury and Akt Signaling

We previously reported that serine-47 (S47) phosphorylation of cytochrome c (Cytc) in the brain results in lower cytochrome c oxidase (COX) activity and caspase-3 activity in vitro. We here analyze the effect of S47 modification in fibroblast cell lines stably expressing S47E phosphomimetic Cytc, un...

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Detalles Bibliográficos
Autores principales:	Kalpage, Hasini A., Wan, Junmei, Morse, Paul T., Lee, Icksoo, Hüttemann, Maik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465522/ https://www.ncbi.nlm.nih.gov/pubmed/32781572 http://dx.doi.org/10.3390/cells9081843

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