Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells

The eukaryotic translation initiation factor 4F complex (eIF4F) is a potential chemotherapeutic target in triple-negative breast cancer (TNBC). This complex regulates cap-dependent translational initiation and consists of three core proteins: eIF4E, eIF4G, and eIF4A1. In this study, we focus on repo...

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Detalles Bibliográficos
Autores principales: Howard, Cory M., Estrada, Matthew, Terrero, David, Tiwari, Amit K., Raman, Dayanidhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465665/
https://www.ncbi.nlm.nih.gov/pubmed/32759815
http://dx.doi.org/10.3390/cancers12082169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465665/
https://www.ncbi.nlm.nih.gov/pubmed/32759815
http://dx.doi.org/10.3390/cancers12082169

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