RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha

In response to estrogens, estrogen receptor alpha (ERα), a critical regulator of homeostasis, is degraded through the 26S proteasome. However, despite the continued presence of estrogen before menopause, ERα protein levels are maintained. We discovered that ERK1/2-RSK2 activity oscillates during the...

Descripción completa

Detalles Bibliográficos
Autores principales: Ludwik, Katarzyna A., Sandusky, Zachary M., Stauffer, Kimberly M., Li, Yu, Boyd, Kelli L., O’Doherty, George A., Stricker, Thomas P., Lannigan, Deborah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465694/
https://www.ncbi.nlm.nih.gov/pubmed/32697984
http://dx.doi.org/10.1016/j.celrep.2020.107931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465694/
https://www.ncbi.nlm.nih.gov/pubmed/32697984
http://dx.doi.org/10.1016/j.celrep.2020.107931

Ejemplares similares