Cargando…

TCGA mRNA Expression Analysis of the Heme Biosynthesis Pathway in Diffusely Infiltrating Gliomas: A Comparison of Typically 5-ALA Fluorescent and Non-Fluorescent Gliomas

5-Aminolevulinic acid (5-ALA) is a fluorescent dye that after metabolization to Protoporphyrin IX (PpIX) by the heme biosynthesis pathway typically leads to visible fluorescence in WHO grade IV but not grade II gliomas. The exact mechanism for high PpIX levels in WHO grade IV gliomas and low PpIX le...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mischkulnig, Mario, Kiesel, Barbara, Lötsch, Daniela, Roetzer, Thomas, Borkovec, Martin, Wadiura, Lisa I., Mercea, Petra A., Jaklin, Florian J., Hervey-Jumper, Shawn, Roessler, Karl, Berger, Mitchel S., Widhalm, Georg, Erhart, Friedrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466145/ https://www.ncbi.nlm.nih.gov/pubmed/32722247 http://dx.doi.org/10.3390/cancers12082043

Ejemplares similares

Heme Biosynthesis mRNA Expression Signature: Towards a Novel Prognostic Biomarker in Patients with Diffusely Infiltrating Gliomas
por: Mischkulnig, Mario, et al.
Publicado: (2021)

5-ALA Fluorescence Is a Powerful Prognostic Marker during Surgery of Low-Grade Gliomas (WHO Grade II)—Experience at Two Specialized Centers
por: Hosmann, Arthur, et al.
Publicado: (2021)

Reply to Stummer, W.; Thomas, C. Comment on “Hosmann et al. 5-ALA Fluorescence Is a Powerful Prognostic Marker during Surgery of Low-Grade Gliomas (WHO Grade II)—Experience at Two Specialized Centers. Cancers 2021, 13, 2540”
por: Hosmann, Arthur, et al.
Publicado: (2021)

The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers
por: Mischkulnig, Mario, et al.
Publicado: (2022)

Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas
por: Mischkulnig, Mario, et al.
Publicado: (2022)

Mapping high-grade glioma immune infiltration to 5-ALA fluorescence levels: TCGA data computation, classical histology, and digital image analysis
por: Lang, Alexandra, et al.
Publicado: (2023)

High Interobserver Agreement in the Subjective Classification of 5‐Aminolevulinic Acid Fluorescence Levels in Newly Diagnosed Glioblastomas
por: Mischkulnig, Mario, et al.
Publicado: (2020)

5-ALA in Suspected Low-Grade Gliomas: Current Role, Limitations, and New Approaches
por: Kiesel, Barbara, et al.
Publicado: (2021)

Prognostic Value of 5-ALA Fluorescence, Tumor Cell Infiltration and Angiogenesis in the Peritumoral Brain Tissue of Brain Metastases
por: Mercea, Petra A., et al.
Publicado: (2021)

High Diagnostic Accuracy of Visible 5‐ALA Fluorescence in Meningioma Surgery According to Histopathological Analysis of Tumor Bulk and Peritumoral Tissue
por: Wadiura, Lisa I., et al.
Publicado: (2020)

Comparison of minimal detectable protoporphyrin IX concentrations with a loupe device and conventional 5-ALA fluorescence microscopy: an experimental study
por: Mischkulnig, Mario, et al.
Publicado: (2023)

SURG-13. EVALUATION OF 5-ALA FLUORESCENCE IN BRAIN METASTASES OF VARIOUS PRIMARY TUMORS: A MULTICENTER STUDY WITH EXPERIENCE IN 157 CASES
por: Mercea, Petra Andreea, et al.
Publicado: (2019)

5-ALA fluorescence in indeterminate grade gliomas
por: Müther, Michael, et al.
Publicado: (2022)

Efficacy, Outcome, and Safety of Elderly Patients with Glioblastoma in the 5-ALA Era: Single Center Experience of More Than 10 Years
por: Kiesel, Barbara, et al.
Publicado: (2021)

Fluorescence-Guided Resection of Malignant Glioma with 5-ALA
por: Kaneko, Sadahiro, et al.
Publicado: (2016)

Treatment of high-grade glioma patients during the COVID-19 pandemic: Impact on overall survival, tumor size and delay of treatment
por: Mischkulnig, Mario, et al.
Publicado: (2023)

The Role of 5-ALA in Low-Grade Gliomas and the Influence of Antiepileptic Drugs on Intraoperative Fluorescence
por: Goryaynov, Sergey A., et al.
Publicado: (2019)

Simultaneous fluorescein sodium and 5-ALA in fluorescence-guided glioma surgery
por: Schwake, Michael, et al.
Publicado: (2015)

Functional Outcomes and Health-Related Quality of Life Following Glioma Surgery
por: De Witt Hamer, Philip C, et al.
Publicado: (2021)

5-Aminolevulinic Acid (5-ALA)-Induced Protoporphyrin IX Fluorescence by Glioma Cells—A Fluorescence Microscopy Clinical Study
por: Pacioni, Simone, et al.
Publicado: (2022)

In Reply: Functional Outcomes and Health-Related Quality of Life Following Glioma Surgery
por: De Witt Hamer, Philip C, et al.
Publicado: (2021)

Macroscopic fluorescence-lifetime imaging of NADH and protoporphyrin IX improves the detection and grading of 5-aminolevulinic acid-stained brain tumors
por: Erkkilä, Mikael T., et al.
Publicado: (2020)

Fluorescence Lifetime Imaging and Spectroscopic Co-Validation for Protoporphyrin IX-Guided Tumor Visualization in Neurosurgery
por: Reichert, David, et al.
Publicado: (2021)

Involvement of White Matter Language Tracts in Glioma: Clinical Implications, Operative Management, and Functional Recovery After Injury
por: Aabedi, Alexander A., et al.
Publicado: (2022)

Editorial: Quality of care of glioma patients
por: Forster, Marie-Therese, et al.
Publicado: (2022)

Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy
por: Leclerc, Pierre, et al.
Publicado: (2020)

Flavin fluorescence lifetime and autofluorescence optical redox ratio for improved visualization and classification of brain tumors
por: Reichert, David, et al.
Publicado: (2023)

High-resolution metabolic imaging of high-grade gliomas using 7T-CRT-FID-MRSI
por: Hangel, Gilbert, et al.
Publicado: (2020)

Corrigendum: Editorial: Quality of care of glioma patients
por: Forster, Marie-Therese, et al.
Publicado: (2022)

Surgical microscope with integrated fluorescence lifetime imaging for 5-aminolevulinic acid fluorescence-guided neurosurgery
por: Erkkilä, Mikael T., et al.
Publicado: (2020)

Correlation of Intraoperative 5-ALA-Induced Fluorescence Intensity and Preoperative (11)C-Methionine PET Uptake in Glioma Surgery
por: Shimizu, Kazuhide, et al.
Publicado: (2022)

The Evoked Potential Score for SSEP and BAEP—A Prognostic Marker for the Long-Term Neurological Outcome in Patients after Poor-Grade Subarachnoid Hemorrhage
por: Wadiura, Lisa I., et al.
Publicado: (2021)

BIMG-04. MAPPING HETEROGENEITY OF HIGH-GRADE GLIOMA METABOLISM USING HIGH RESOLUTION 7T MRSI
por: Hangel, Gilbert, et al.
Publicado: (2021)

5-Aminolevulinic Acid Induced Fluorescence Is a Powerful Intraoperative Marker for Precise Histopathological Grading of Gliomas with Non-Significant Contrast-Enhancement
por: Widhalm, Georg, et al.
Publicado: (2013)

Preclinical modeling of lower-grade gliomas
por: Tang, Lilly W., et al.
Publicado: (2023)

PSMA Expression in 122 Treatment Naive Glioma Patients Related to Tumor Metabolism in (11)C-Methionine PET and Survival
por: Traub-Weidinger, Tatjana, et al.
Publicado: (2021)

Prediction of Intraoperative Fluorescence of Brain Gliomas: Correlation between Tumor Blood Flow and the Fluorescence
por: Batalov, Artem I., et al.
Publicado: (2021)

Fluorescence-Guided Surgery and Biopsy in Gliomas with an Exoscope System
por: Piquer, José, et al.
Publicado: (2014)

Experience Profiling of Fluorescence-Guided Surgery I: Gliomas
por: Ji, So Young, et al.
Publicado: (2019)

ALA- and ALA-hexylester-induced protoporphyrin IX fluorescence and distribution in multicell tumour spheroids
por: Bigelow, C E, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_4vusq726p0gtmrc7c3id95far1