Glucose Overload Inhibits Glutamatergic Synaptic Transmission: A Novel Role for CREB-Mediated Regulation of Synaptotagmins 2 and 4

Glucose metabolism derangement is critically involved in the age-related memory loss but the underlying molecular mechanisms are still poorly understood. In a mouse model of type 1 diabetes we found memory impairment associated with inhibition of the transcription factor CREB and alteration of pre-...

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Detalles Bibliográficos
Autores principales: Ripoli, Cristian, Spinelli, Matteo, Natale, Francesca, Fusco, Salvatore, Grassi, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466440/
https://www.ncbi.nlm.nih.gov/pubmed/32974347
http://dx.doi.org/10.3389/fcell.2020.00810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466440/
https://www.ncbi.nlm.nih.gov/pubmed/32974347
http://dx.doi.org/10.3389/fcell.2020.00810

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