Cargando…

Glucose Overload Inhibits Glutamatergic Synaptic Transmission: A Novel Role for CREB-Mediated Regulation of Synaptotagmins 2 and 4

Glucose metabolism derangement is critically involved in the age-related memory loss but the underlying molecular mechanisms are still poorly understood. In a mouse model of type 1 diabetes we found memory impairment associated with inhibition of the transcription factor CREB and alteration of pre-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ripoli, Cristian, Spinelli, Matteo, Natale, Francesca, Fusco, Salvatore, Grassi, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466440/ https://www.ncbi.nlm.nih.gov/pubmed/32974347 http://dx.doi.org/10.3389/fcell.2020.00810

Ejemplares similares

Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms
por: Fusco, Salvatore, et al.
Publicado: (2019)

Neural Stem Cell-Derived Exosomes Revert HFD-Dependent Memory Impairment via CREB-BDNF Signalling
por: Spinelli, Matteo, et al.
Publicado: (2020)

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
por: Spinelli, Matteo, et al.
Publicado: (2017)

Synaptotagmin 7 functions as a Ca(2+)-sensor for synaptic vesicle replenishment
por: Liu, Huisheng, et al.
Publicado: (2014)

Plasma BDNF Levels Following Transcranial Direct Current Stimulation Allow Prediction of Synaptic Plasticity and Memory Deficits in 3×Tg-AD Mice
por: Cocco, Sara, et al.
Publicado: (2020)

CREB3L1 and CREB3L2 control Golgi remodelling during decidualization of endometrial stromal cells
por: Pittari, Daniele, et al.
Publicado: (2022)

The resealing factor S100A11 interacts with annexins and extended synaptotagmin-1 in the course of plasma membrane wound repair
por: Ashraf, Arsila P. K., et al.
Publicado: (2022)

Ketamine disrupts neuromodulatory control of glutamatergic synaptic transmission
por: Lur, Gyorgy, et al.
Publicado: (2019)

Synaptotagmin 7 switches short-term synaptic plasticity from depression to facilitation by suppressing synaptic transmission
por: Fujii, Takaaki, et al.
Publicado: (2021)

Role of Flavonoids in the Treatment of Iron Overload
por: Wang, Xiaomin, et al.
Publicado: (2021)

Mitochondrial Proteome of Affected Glutamatergic Neurons in a Mouse Model of Leigh Syndrome
por: Gella, Alejandro, et al.
Publicado: (2020)

Synaptotagmin-7 Is an Asynchronous Calcium Sensor for Synaptic Transmission in Neurons Expressing SNAP-23
por: Weber, Jens P., et al.
Publicado: (2014)

The C(2)A domain of synaptotagmin is an essential component of the calcium sensor for synaptic transmission
por: Bowers, Matthew R., et al.
Publicado: (2020)

Anodal transcranial direct current stimulation boosts synaptic plasticity and memory in mice via epigenetic regulation of Bdnf expression
por: Podda, Maria Vittoria, et al.
Publicado: (2016)

Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling
por: Gao, Chong, et al.
Publicado: (2022)

The p38(MAPK)-MK2 Signaling Axis as a Critical Link Between Inflammation and Synaptic Transmission
por: Beamer, Edward, et al.
Publicado: (2021)

CREB3 Transcription Factors: ER-Golgi Stress Transducers as Hubs for Cellular Homeostasis
por: Sampieri, Luciana, et al.
Publicado: (2019)

Loss of Leptin-Induced Modulation of Hippocampal Synaptic Trasmission and Signal Transduction in High-Fat Diet-Fed Mice
por: Mainardi, Marco, et al.
Publicado: (2017)

CREB1 and ATF1 Negatively Regulate Glutathione Biosynthesis Sensitizing Cells to Oxidative Stress
por: Zhao, Lina, et al.
Publicado: (2021)

Innate Immune Cells in Pressure Overload-Induced Cardiac Hypertrophy and Remodeling
por: Liu, Xin, et al.
Publicado: (2021)

Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms
por: Cai, Chenhui, et al.
Publicado: (2022)

The Effect of Bacterial Endotoxin LPS on Serotonergic Modulation of Glutamatergic Synaptic Transmission
por: Bernard, Jate, et al.
Publicado: (2020)

Dysfunction of Glutamatergic Synaptic Transmission in Depression: Focus on AMPA Receptor Trafficking
por: He, Jin-Gang, et al.
Publicado: (2022)

Differential Roles for Snapin and Synaptotagmin in the Synaptic Vesicle Cycle
por: Yu, Szi-Chieh, et al.
Publicado: (2013)

The calcium sensor synaptotagmin 7 is required for synaptic facilitation
por: Jackman, Skyler L., et al.
Publicado: (2016)

Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling
por: Brai, Emanuele, et al.
Publicado: (2015)

Nutrient-Dependent Changes of Protein Palmitoylation: Impact on Nuclear Enzymes and Regulation of Gene Expression
por: Spinelli, Matteo, et al.
Publicado: (2018)

Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline
por: Spinelli, Matteo, et al.
Publicado: (2019)

Analysis of Synaptotagmin, SV2, and Rab3 Expression in Cortical Glutamatergic and GABAergic Axon Terminals
por: Bragina, Luca, et al.
Publicado: (2012)

Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability
por: Xian, Weiwei, et al.
Publicado: (2021)

Absence of Desmin Results in Impaired Adaptive Response to Mechanical Overloading of Skeletal Muscle
por: Joanne, Pierre, et al.
Publicado: (2021)

Iron Overload Induces Oxidative Stress, Cell Cycle Arrest and Apoptosis in Chondrocytes
por: Karim, Asima, et al.
Publicado: (2022)

Upregulation of Neogenin-1 by a CREB1-BAF47 Complex in Vascular Endothelial Cells is Implicated in Atherogenesis
por: Li, Nan, et al.
Publicado: (2022)

High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms
por: Natale, Francesca, et al.
Publicado: (2022)

Cyclin-Dependent Kinase 1 Is Essential for Muscle Regeneration and Overload Muscle Fiber Hypertrophy
por: Kobayashi, Yutaka, et al.
Publicado: (2020)

Interplay Between BALL and CREB Binding Protein Maintains H3K27 Acetylation on Active Genes in Drosophila
por: Shaukat, Ammad, et al.
Publicado: (2021)

Synaptotagmin-1 is the Ca(2+) sensor for fast striatal dopamine release
por: Banerjee, Aditi, et al.
Publicado: (2020)

Peptide and Lipid Modulation of Glutamatergic Afferent Synaptic Transmission in the Solitary Tract Nucleus
por: Andresen, Michael C., et al.
Publicado: (2013)

Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex
por: Kerkhofs, Amber, et al.
Publicado: (2018)

Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission
por: Mira, Rodrigo G., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v8f9jt28kj0s20lbtmgsd1bekf