Matrix Stiffness-Upregulated MicroRNA-17-5p Attenuates the Intervention Effects of Metformin on HCC Invasion and Metastasis by Targeting the PTEN/PI3K/Akt Pathway

BACKGROUND: Metformin, a traditional first-line anti-hyperglycemic agent for diabetes, recently exhibits better antitumor effect in hepatocellular carcinoma (HCC). However, its resistance and tolerance mechanism in HCC remains largely unknown. Here, we investigated whether increased matrix stiffness...

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Detalles Bibliográficos
Autores principales: Gao, Xiangyu, Qiao, Xiaona, Xing, Xiaoxia, Huang, Jinya, Qian, Jiali, Wang, Yi, Zhang, Yawen, Zhang, Xi, Li, Miao, Cui, Jiefeng, Yang, Yehong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466473/
https://www.ncbi.nlm.nih.gov/pubmed/32974191
http://dx.doi.org/10.3389/fonc.2020.01563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466473/
https://www.ncbi.nlm.nih.gov/pubmed/32974191
http://dx.doi.org/10.3389/fonc.2020.01563

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