Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation

CDK5/p25 kinase plays a major role in neuronal functions, and is hyperactivated in several human cancers including glioblastoma and neurodegenerative pathologies such as Alzheimer's and Parkinson's. CDK5 therefore constitutes an attractive pharmacological target. Since the successful disco...

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Detalles Bibliográficos
Autores principales: Peyressatre, Marion, Arama, Dominique Patomo, Laure, Arthur, González-Vera, Juan A., Pellerano, Morgan, Masurier, Nicolas, Lisowski, Vincent, Morris, May C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466635/
https://www.ncbi.nlm.nih.gov/pubmed/32974274
http://dx.doi.org/10.3389/fchem.2020.00691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466635/
https://www.ncbi.nlm.nih.gov/pubmed/32974274
http://dx.doi.org/10.3389/fchem.2020.00691

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