Cargando…

Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells

BACKGROUND: Nucleus pulposus (NP) cell dysfunction and apoptosis contribute to disc degeneration. Dioscin, a natural steroid saponin, has been demonstrated to have anti-inflammatory, antiapoptotic, and antioxidative effects in various diseases. However, little is known about the roles of dioscin in...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Longhui, Gu, Yuntao, Zhao, Hai, Chen, Rong, Chen, Wensheng, Qi, Hao, Gao, Weisong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466834/
https://www.ncbi.nlm.nih.gov/pubmed/32841225
http://dx.doi.org/10.12659/MSM.923386