SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4

The conversion of a non-T cell-inflamed into a T cell-inflamed tumor microenvironment (TME) is a key to sensitizing tumors to T-cell-based immunotherapies. Recent data show that the extracellular superoxide dismutase (SOD3) alters endothelial basement membrane (EC-BM) composition, providing permissi...

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Autores principales: Carmona-Rodríguez, Lorena, Martínez-Rey, Diego, Mira, Emilia, Mañes, Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466848/
https://www.ncbi.nlm.nih.gov/pubmed/32934887
http://dx.doi.org/10.1080/2162402X.2020.1794163
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author Carmona-Rodríguez, Lorena
Martínez-Rey, Diego
Mira, Emilia
Mañes, Santos
author_facet Carmona-Rodríguez, Lorena
Martínez-Rey, Diego
Mira, Emilia
Mañes, Santos
author_sort Carmona-Rodríguez, Lorena
collection PubMed
description The conversion of a non-T cell-inflamed into a T cell-inflamed tumor microenvironment (TME) is a key to sensitizing tumors to T-cell-based immunotherapies. Recent data show that the extracellular superoxide dismutase (SOD3) alters endothelial basement membrane (EC-BM) composition, providing permissive signals that enhance tumor infiltration by effector T cells. ABBREVIATIONS: AJ, adherens junction; EC, endothelial cell; EC-BM, endothelial basement membrane; HIF, hypoxia-inducible factor; ICAM-1, intercellular adhesion molecule-1; LAMA4, laminin-α4; SOD3, superoxide dismutase-3; TME, tumor microenvironment; VCAM-1, vascular cell adhesion molecule-1; VEGF, vascular-endothelial growth factor
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spelling pubmed-74668482020-09-14 SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4 Carmona-Rodríguez, Lorena Martínez-Rey, Diego Mira, Emilia Mañes, Santos Oncoimmunology Author's View The conversion of a non-T cell-inflamed into a T cell-inflamed tumor microenvironment (TME) is a key to sensitizing tumors to T-cell-based immunotherapies. Recent data show that the extracellular superoxide dismutase (SOD3) alters endothelial basement membrane (EC-BM) composition, providing permissive signals that enhance tumor infiltration by effector T cells. ABBREVIATIONS: AJ, adherens junction; EC, endothelial cell; EC-BM, endothelial basement membrane; HIF, hypoxia-inducible factor; ICAM-1, intercellular adhesion molecule-1; LAMA4, laminin-α4; SOD3, superoxide dismutase-3; TME, tumor microenvironment; VCAM-1, vascular cell adhesion molecule-1; VEGF, vascular-endothelial growth factor Taylor & Francis 2020-07-12 /pmc/articles/PMC7466848/ /pubmed/32934887 http://dx.doi.org/10.1080/2162402X.2020.1794163 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author's View
Carmona-Rodríguez, Lorena
Martínez-Rey, Diego
Mira, Emilia
Mañes, Santos
SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4
title SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4
title_full SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4
title_fullStr SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4
title_full_unstemmed SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4
title_short SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4
title_sort sod3 boosts t cell infiltration by normalizing the tumor endothelium and inducing laminin-α4
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466848/
https://www.ncbi.nlm.nih.gov/pubmed/32934887
http://dx.doi.org/10.1080/2162402X.2020.1794163
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