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SIR2 Expression Noise Can Generate Heterogeneity in Viability but Does Not Affect Cell-to-Cell Epigenetic Silencing of Subtelomeric URA3 in Yeast

Chromatin structure clearly modulates gene expression noise, but the reverse influence has never been investigated, namely how the cell-to-cell expression heterogeneity of chromatin modifiers may generate variable rates of epigenetic modification. Sir2 is a well-characterized histone deacetylase of...

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Detalles Bibliográficos
Autores principales: Liu, Jian, Mosser, Laureline, Botanch, Catherine, François, Jean-Marie, Capp, Jean-Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466964/
https://www.ncbi.nlm.nih.gov/pubmed/32727919
http://dx.doi.org/10.1534/g3.120.401589