Safety range of free valproic acid serum concentration in adult patients

BACKGROUND: Therapeutic drug monitoring (TDM) is recommended during valproic acid (VPA) use, and total serum concentration has been widely adopted. However, the free form of VPA is responsible for its pharmacologic and toxic effects, and the total and free concentrations are highly discordant becaus...

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Detalles Bibliográficos
Autores principales: Tseng, Yu-Ju, Huang, Shih-Ying, Kuo, Chih-Hsuan, Wang, Chen-Yu, Wang, Kuo-Chuan, Wu, Chien-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467252/
https://www.ncbi.nlm.nih.gov/pubmed/32877431
http://dx.doi.org/10.1371/journal.pone.0238201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467252/
https://www.ncbi.nlm.nih.gov/pubmed/32877431
http://dx.doi.org/10.1371/journal.pone.0238201

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