The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth

BACKGROUND: The mechanistic target of rapamycin complex 1 (mTORC1) is a nutrient-sensing pathway and a key regulator of amino acid and glucose metabolism. Dysregulation of the mTOR pathways is implicated in the pathogenesis of metabolic syndrome, obesity, type 2 diabetes, and pancreatic cancer. OBJE...

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Detalles Bibliográficos
Autores principales: Soliman, Ghada A, Shukla, Surendra K, Etekpo, Asserewou, Gunda, Venugopal, Steenson, Sharalyn M, Gautam, Nagsen, Alnouti, Yazen, Singh, Pankaj K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467276/
https://www.ncbi.nlm.nih.gov/pubmed/32908958
http://dx.doi.org/10.1093/cdn/nzaa131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467276/
https://www.ncbi.nlm.nih.gov/pubmed/32908958
http://dx.doi.org/10.1093/cdn/nzaa131

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